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KMID : 0370219980420030324
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Yakhak Hoeji
1998 Volume.42 No. 3 p.324 ~ p.329
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Effect of Glycyrrhizin on Apoptosis of Transplanted-L1210 Cells in Mice
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은재순/Eun JS
권진/오찬호/Kwon J/Oh CH
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Abstract
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These experiments were conducted to investigate effects of glycyrrhizin (GL) on apoptosis of transplanted-L1210 cells in mice. GL induced apoptosis of transplanted-Ll2lO cells. GL increased nitric oxide production from peritoneal macrophages of L1210 cells-transplanted mice. NOC12, nitric oxide donor, induced apoptosis of L1210 cells in vitro. The apoptosis of L1210 cells were enhanced by co-culture of the peritoneal macrophages of GL-administered mice and L1210 cells in vitro, and was inhibited by L-NMMA. These results suggest that the apoptosis of transplanted-Ll2lO cells is partly induced by nitric oxide produced from peritoneal macrophages in GL-administered mice.
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